2021-01-01

4-1BB (CD137) för att främja potent, tumörriktad T-cellsaktivering. inhibition induced by a 4-1BB x 5T4 ADAPTIR™ bispecific antibody.

Alfonso Sanchez (CD137) och T-cellssignalerande CD3-zeta. molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci U. S A. 1989 CD137 is expressed in human atherosclerosis and promotes development of trophoblast to obtain mouse-human cross-reacting antibodies against normal 4-1BB (CD137) för att främja potent, tumörriktad T-cellsaktivering. inhibition induced by a 4-1BB x 5T4 ADAPTIR™ bispecific antibody. av M Hernberg — Anti-CD137 kostimulatorisk.

14G2A antibody. CH2CH3. Hinge domain. CD28 signaling domain. CD3 zeta signaling domain. CD137 signaling domain. MSGV retroviral vector.

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Rat Monoclonal CD137 antibody for FACS, WB. Order anti-CD137 antibody ABIN1169067.

Targeting CD137 or its ligand (CD137L) has been studied, aiming to enhance anticancer immune responses. Urelumab (BMS-663513 or anti-4-1BB antibody) is a fully human IgG4 monoclonal antibody developed by Bristol-Myers Squibb for the treatment of cancer and solid tumors. Urelumab targets the extracellular domain of CD137. CD137 (4-1BB) is a member of the TNFR superfamily that represents a promising target for cancer immunotherapy. Recent insights into the function of TNFR agonist antibodies implicate epitope, affinity, and IgG subclass as critical features, and these observations help explain the limited activity and … This antibody recognizes the CD137 (4-1BB) antigen, a 30 kDa glycoprotein of the tumor necrosis factor (TNF) receptor superfamily. CD137 is mainly expressed on activated CD4+ and CD8+ T cells, activated B cells, and natural killer cells, but can also be found on resting monocytes and dendritic cells.As a costimulatory molecule it is involved in the activation and survival of CD4+ or CD8+ T 71 CD137 Primary Antibodies: Thermo Fisher antibodies are validated for applications including western blotting, immunocytochemistry, flow cytometry, and chromatin immunoprecipitation.

It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
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Agonistic monoclonal antibodies ( 12 Apr 2019 Anti-CD137 antibody stimulates and activates effector T lymphocytes (e.g., stimulating CD8 T lymphocytes to produce INFγ), NKTs, and APCs (e.g., macrophages) [26,28,30,32,33,35,37,38] to kill oncogenic cells selectively. Recombinant Monoclonal Antibody. Detection of Human 4-1BB/TNFRSF9/ CD137 antibody by Western Blot. (3). This antibody recognizes the CD137 (4-1BB) antigen, a 30 kDa glycoprotein of the tumor necrosis factor (TNF) receptor superfamily.

CD137 engagement is shown to be required for CD8+ T cell survival and memory formation.
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CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.

Tested in Immunofluorescence (IF) and Flow Cytometry (Flow) applications. This antibody reacts with Human samples. Invitrogen Anti-CD137 Polyclonal, Catalog # PA5-106494. Tested in Western Blot (WB), Immunofluorescence (IF) and Immunocytochemistry (ICC) applications. This antibody reacts with Human, Rat samples. The selective expression of CD137 on cells of the immune system (e.g., T and DC cells) and oncogenic cells in several types of cancer leads this molecule to be an attractive target to discover cancer immunotherapy.

CD137 antibody LS-C88297 is an unconjugated mouse monoclonal antibody to human CD137 (TNFRSF9 / 4-1BB) (Ectodomain). Validated for Flow and IF.

A fully human IgG4 anti-CD137 antibody is under development with signs of clinical activity and cases of severe liver toxicity that seem to be on-target and dose-dependent effects.

Utomilumab (PF-05082566) targets this receptor to stimulate a more intense immune system attack on cancers. It is a fully human IgG2 monoclonal antibody. It is in early clinical trials.